|First Appearance||Cortex Chaos|
Doctor N. Tangle is an evil doctor with plants growing out of his body. He was one of the new characters planned for the unreleased game, Cortex Chaos, and was going to be part of the evil doctors' group.
|Main Characters||Doctor Neo Cortex | Nina Cortex | Cortex clones|
|Known Doctors||Doctor N.Tangle | Nitros Oxide | Doctor N. Gin | Doctor Nitrus Brio | Doctor Nefarious Tropy | Doctor N. Tombed | Doctor N. Tertain|
|Weapons||Cortex's Ray Gun | Bomb-Zooka | Magnet Magum | Teleporter Ray|