Dr. Neo Cortex is usually the last boss of the games, appearing as such in all but in Crash Twinsanity (where Cortex is the first boss and later used by the player), Crash of the Titans (where Cortex is the first boss) and Crash Bandicoot 2: N-Tranced, where he is not a boss due to only appearing in the multiplayer games.
Cortex (コルテックスと いっきうち lit. Duel with Cortex in Japanese) is the sixth and final boss of Crash Bandicoot and he has five hit points. Crash is on top of Cortex's airship, flying around Cortex Castle which is on fire, possibly from the fights with Dr. Nitrus Brio (as he wrecks his office) and Pinstripe (as he shoots the reactor), set at sunset. Cortex, on his hoverboard, flies over to Crash and says "Darn you, Crash Bandicoot!". Then, using his blaster, starts blasting energy bolts which come in pink that homes in on Crash, blue that goes up, down, across the bottom and top, and green which Crash can spin back at Cortex. Don't try to jump at him as you'll go right through him.
On the first round, Cortex will fire two pinks and one green. Spin it back at him and it'll take a hit point from him.
On the second round, he'll fire a pink, a blue, another pink, two more blues, and two greens. Once you hit one of them, a large green will be above Cortex. Spin another green into it and it'll land on Cortex. By this point he'll just have three hit points.
On the third round, you'll need three greens. He'll fire a pink, two blues, another pink, and a green. He'll now fire a pink, three blues, and a green. Add that to the giant green above Cortex and he'll fire another green. Once three greens have been added to the giant green and land on Cortex, he'll now have two hit points.
On the fouth round, this time he'll just use pink and green. He'll fire fast rows of pinks and a single green at the end, hit them twice to damage Cortex. Surprisingly, on his last hit point, Cortex will fire a single, pitiful green. Spin it a him and his hoverboard will blow up, and he'll plummet down onto his island.
This corresponds to a save file at this level (70%, 2 keys, 0 gems).
Cortex is the fifth and final boss in Crash Bandicoot 2: Cortex Strikes Back and, with the exception of Dr. N. Gin, has three hit points as the rest of the bosses. This boss battle is held in space. Crash's goal is to defeat Cortex before he gets to the space station and blasts everyone on Earth with the Cortex Vortex, turning everyone into Cortex's mindless slaves. Crash uses a jet pack in the fight so he can keep up with Cortex. Crash has to watch that he does not bump into asteroids or mines, if he hit one of them, he will slow down. Cortex doesn't have any attacks, he will only run away and occasionally slow down for Crash to catch up to him. Once Crash spins Cortex three times, he'll go shooting down the space tube, going out to nowhere, and screams back "Nooooooooooo! You haven't seen the last of me, Crash Bandicoot!". If Cortex escapes then, followed by evil laughter, Crash will lose a life and will have to start the boss fight again.
- Many fans consider this as one of the worst bosses (as well as final bosses) in the entire Crash Bandicoot franchise, due to how easy Cortex is, even compare to the fight from in the first game, and how he never attacks Crash Bandicoot.
N. Cortex (でたぞ ネオ・コルテックス lit. He Comes Out, Neo Cortex in Japanese) is the fifth and final boss for the third time, he has three hit points and Uka Uka fights alongside him. As soon as Crash arrives, Uka Uka goes onto Cortex's face (who's on his old hoverboard) and jumps up and down furiously saying "Crash Bandicoot, for the last time, give the crystals to me!" but takes care of Aku Aku first.
Unfortunately, Crash can't have an Aku Aku mask. so Crash will have to do a no damage run against Cortex, Cortex will be protected by a force-field but it will go down in a bit. Crash needs to keep his eye on the dueling masks who use lasers against each other that go to the length of the room. He must also watch out for Cortex's red energy bolts that he fires while dodging the lasers. After about three blasts, Cortex will throw five mines onto the ground, his shield will shut down, and the masks stop fighting, giving you the chance to spin him off his hoverboard when he's on the ground. Continue spinning him towards the shaft in the middle of the room. A noise is heard, one of his hit points disappears, and Uka Uka goes down to save him.
When they come back out Uka Uka is even more mad and begin shooting flames, which aren't harmful for Crash and puts Cortex back on his hoverboard. While Cortex does the same thing as before, Uka Uka and Aku Aku turn into a tornado and spin around the room which can harm Crash on contact, repeat the same strategy like before to damage Cortex.
On the third round, they head for Crash, spinning faster and they make a big explosion. Repeat the same thing with Cortex. Once he goes down the shaft a final time Crash wins and gets the Crash Dash power.
If the player returns to the boss fight after collecting all the crystals, gems and relics, Uka Uka says "Yes, it is true! The bandicoot has brought all of the crystals, and all of the gems to me! Ultimate power is mine! The world as we know it, is about to end!" at the start.
Hint: On the last round, the explosion from the masks could destroy Cortex's mines, giving you a clearer way to hit Cortex.
The boss battle is fought inside the Time Twister Machine.
In the N. Sane Trilogy remake of the first three games, in which Coco is a playable character in each one, she cannot enter any of the boss levels, sans N. Gin in Warped.
Cortex is the final boss and he has 4 hitpoints where he is fought along with Crunch and The Elementals, Cortex himself doesn't do much fighting as he just watch the battle (Crunch does most of the fighting), After Crash shoots Crunch with the bazooka Crunch will hop behind Cortex and hit him in the back of the head, sending him flying off the platform. Crash then needs to spin him before Uka Uka picks him up, repeatthis three more times, and you beat the game.
Cortex (ねらいを はずせ！ lit. Let the Aiming Miss! in Japanese) is the last boss in Crash Bandicoot: The Huge Adventure and he has 3 hit points.
Cortex will use the Planetary Minimizer to shoot Crash. First, he will shoot across the room twice. Then he'll try to shoot Crash. Stand on one of the platforms above Crash and make Cortex shoot one of the colored gems. This will take one of his hit points. Now he will shoot zigzag across the room. Make him shoot the colored gem again. On the last round, he will shoot zigzag again, but this time he sometimes shoots upwards. Do the same thing again to defeat him.
Cortex is the last boss and has two hitpoints. He will be in a spaceship with Ripto. They then reveal two giant arms on their spaceship; Crash must shoot off the arms. After both arms are destroyed under 1 minute, Crash wins.
In Crash Twinsanity, this is the first time in Crash history where Cortex is not the final boss of the game, rather the first boss of the game. He has three hitpoints. The fight starts where Cortex hops on his rocketsled and starts shooting Crash with rapid fire of small green energy balls from his pistol. After all the blasts he shoots have been dodged, he charges a bigger blast. Spinning it will make the blast fly back at him, making him lose a hitpoint. The blast breaks his rocketsled and makes him fall onto the arena. Then, he teleports around the arena starts throwing bombs at Crash. While throwing bombs he says quotes mentioning characters "This is from Tiny, this is from Dingodile, Ripper Roo you shouldn't have, Pinstripe how thoughtful". Only Dingodile would appear later on in the game, appearing as a boss, while the other three only make a cameo appearance.
When a bomb hits a tile other that the central one, it will fall down, making less space to dodge the following blasts. He throws five bombs and makes three tiles fall. After shooting small blasts, he will shoot another big blast from his gun that Crash can spin back, blowing up his rocketsled and sending him flying to the ground again. He warps back on top of the arena, then he gets on another rocketsled. He throws more bombs, making remaining tiles fall, leaving only the central tile remaining. This time, there will be a target showing where Cortex will fire rapid fire energy balls, but it can be easily dodged. Then Cortex shoots his final blast. Returning it makes the fight with Cortex end but he calls Mecha-Bandicoot to fight Crash.
Crash of the Titans (Main console versions)
Cortex's boss is the first boss. After Crash jacks Yuktopus, he needs to destroy all of the walls that are supporting the platforms that Cortex is standing on. When all three platforms are gone, you win the fight.
Hint: Cortex won't attack you while you are doing this but make sure to keep fending of the attacking Titans while you are doing this to stop Yuktopus's health from going down.
Crash of the Titans (GBA)
Cortex is the first boss and has ten hitpoints. Crash must hit him at least ten times. Once this is done, he wins. He, along with the previous bosses and other Titans, will battle Crash for a second time as the final boss. Use the same ways as before to defeat them.
Cortex is the third and final boss of Crash: Mind Over Mutant, he has 36 hitpoints. Cortex will drink a potion, transforming him into a ferocious beast. Crash must jack Grimly to slow down time to hit Cortex without getting hit by his blasts (hit him 28 times). After this, Crash must fight him directly (hit him 8 times), so he can jack him. Cortexa attacks primary consist of spinning around and causing a pink whirlwind to appear around him all the while launch pink energy balls that bounces around the arena, Crash must then defeat some enemies until a giant spin switch appears, use Cortex's special move while standing on it, then use Cortex's jump attack onto a giant red button, which is the Space Head self-destruct. After presing the button, Crash wins the battle.