Game Over screens appear when the player dies with the life count currently on 0. Though it doesn't actually mean the game is over and must be restarted from the beginning, it usually means players could quit and return to the title screen or continue and return to the warp room with the life count resetting to its base number, 4.
The words "GAME OVER" appear similar to how the word "CRASH" does in the start menu. A ticking noise is heard followed by the sound of an explosion and the words pop towards the screen and then fall back (as if an explosion happened behind them). Crash is then seen running from the left to the right side of the screen with Cortex chasing him (the same animation from the first cutscene when Crash escapes).
Selecting Yes on the Continue? prompt will make the player return to the last save point with a total of 4 lives. Selecting No returns to the title screen.
Cortex's head appears and says "Game Over" before laughing evilly.
Selecting Yes will make Cortex say "Play again, Crash" and disappear. Crash then returns to the warp room with 4 lives. Selecting No will make Cortex say "I guess you didn't have what it takes, Crash" and disappear. The player is then returned to the title screen.
Uka Uka appears with Cortex's head hidden behind him. It is similar to their Time Twister message except the vortex is dark orange instead of blue. Uka Uka says "GAME OVER!".
Selecting Yes will make Uka Uka say "When will you ever learn? You miserable bandicoots!" and both Uka Uka and Cortex disappear. Crash returns to the game with 4 lives. Selecting No will make Uka Uka move out of the way revealing Cortex's head, Cortex then says "Goodbye for now". They both disappear and the player is returned to the title screen.
Cortex appears in the room from the opening cutscene. He says "Giving up?" and subtly nods his head as to convince the player to do so.
Continue = Cortex exclaims "Get ready to face my wrath, Crash Bandicoot!" and laughs manically or "Curse you, bandicoot!" The player is then returned to the warp room with 4 lives.
Quit = Cortex yells "Ha ha, at last the world is ours!" or "Quiting so soon? And on such an easy level. ...Oh well. Ta ta." or "Oh dear. The lazy reluctant hero gives up. Go figure." or "Well then, it's game over." or "The world is finally ours!"and laughs manically. The player is then returned to the title screen.
Twinsanity has a different Game Over screen for each character currently being played as. Crash's shows him laying down on his back, looking up. Cortex's shows him beaten up, Nina's shows her tied up and Crash and Cortex's shows Cortex with a broken arm and Crash laying face down with his feet in the air. Even Mecha-Bandicoot has his own screen, where it shows him laying down on his belly. Originally when the player lost all of their lives, there was going to be dialogue where the Evil Twins would taunt them at the Game Over screen. This was scrapped, possibly due to time constraints. However, the dialogue does exist.
The 'Continue' and 'Quit Game' options are exactly what the player would expect them to be.
The overall look is similar to when an episode is finished. The words "Game Over" appear surrounded by swirly patterns and Crash's shoe print. The two options do the same as other games, they are just worded differently.
NOTE: All other games don't have Game Over screen as they don't use lives at all.
The background turns like the slot screen while the words in yellow say "GAME OVER" appear.
The game over screen is similar to Crash 3's game over screen, sans the black background and Uka Uka appearing from the bottom of the screen. The option to retry the level or not will then appear. After a few seconds after the options appear, Uka Uka will chuckle evilly.
For the remasters of Crash 1 and 2, Uka Uka is in darkness (probably to keep him mysterious).