The Mega-Mix is a combination of the left side of the head of Dr. Neo Cortex, the right side of the head of Dr. N Gin, the torso and arms of Tiny Tiger, and the legs and tail of Dingodile. After the transformation, Mega-Mix chased Crash through the hazardous space station, until Crash made it to the exit and escaped with a space motorcycle. Mega-Mix was "destroyed", when the space station exploded, separating the villians' bodies from each other. Mega-Mix is playable in Crash Bandicoot 2: N-Tranced in the multiplayer minigames.
- Mega-Mix is the only boss in the Crash series that is invincible (meaning that it has no hit points, so it can't be defeated).
- When Crash collides into Mega-Mix with invincibility, it will not do anything.
- After defeating Crash, it'll laugh.