Toxic Waste is a recurring hazard in the Crash series, where it is seen only a few times in the games.
In the minigame Toxic Dash, the arena is surrounded with waste and there is a pool of it in the center of it, where a sludge monster arises.
Toxic waste is scattered everywhere in the level Boiler Room Doom, where Crash must avoid Cortex falling in it. It is also found in small pools in Classroom Chaos. Crash is then pursued by a large rising pool of it.
Toxic waste is found where the Sludges are first found in the level Operation Overboard, where it will cause a small amount of damage. Sludges are also immune to it. It also appears in the level The Calamityville Horror.
Like in the previous game, waste is found in small pools in the Junkyard, and it is also sprayed out, which will even hurt Sludges.